Posts Tagged ‘causes of kidney disease’

Urinary Tract

by on Sunday, May 9, 2010 20:48 under Health.

Read full story


The kidneys produce urine and serve a number of important functions, including maintaining fluid balance and blood pressure and eliminating waste products. They are very complex and efficient filters of the blood, allowing unnecessary components to pass into the urine while returning 99 percent of the filtered fluid to the circulatory system.

The kidneys adjust to the body’s fluid needs. For example, a dehydrated individual will produce less urine, allowing the body to conserve water. The kidneys also adjust the salt and mineral composition of the blood. When a kidney is damaged, diseased, or receiving an inadequate supply of blood, it cannot carry out its filtering functions properly. When this occurs, certain components of blood such as protein, sugar, and red blood cells may leak into the urine.

Normally the clear yellow urine produced by each kidney flows continuously through a narrow, muscular tube called the ureter to the bladder, where it is stored until automatic or voluntary input from the nervous system causes it to be eliminated. This process involves simultaneous contraction of muscles within the bladder wall and relaxation of muscles (called the sphincter) at the bladder’s outlet.

Painful urination (dysuria)

Discomfort while passing urine can he caused by one of the following situations:

• Infection (see below)

• Irritation from something coming in direct

contact with the genital area, such as bubble bath

or other soapy material in the tub, new laundry

soap, creams, or lotions

• Trauma

• A foreign body in the vagina or urinary tract (see genital care and concerns)

Any time your child complains of painful urination or if you notice a distinctly abnormal color of the urine (especially a reddish tinge that could indicate that blood is present), contact your child’s physician as soon as possible. If a child is having difficulty urinating because of pain, you can help by placing her in a bathtub of warm water and allowing her to urinate there.

Kidney disease

Changes in the characteristics or amount of urine  may result from a disorder of the kidney itself or from a problem in the ureter or bladder. Decreased urine production may be caused specifically by dehydration or kidney disease, or obstruction to the flow of urine. There are  many types of kidney diseases, but they cause only a limited number of symptoms.

Decreased or (more rarely) increased urine production

Passage of blood, which may be visible to the naked eye or detected only by chemical tests or microscopic examination

Sugar (glucose) in the urine, which is virtually always associated with a high level of glucose in the blood (diabetes)

Increased amounts of protein in the urine, which can usually be detected by a simple chemical test in the physician’s office

Swelling of the hands, ankles, feet, scrotum, or eyelids (called edema)

Pain in the mid-back or flank area on one side of the body

Fever, which may be a sign of infection within or adjacent to a kidney

Inceased urine production (polyuria)

Inceased urine production can be a normal response if a child drinks a lot of fluid, or it can indicate are serious problem. Kidneys will produce an abnormal amount of urine for three basic reasons:

Kidney damage prevents the kidneys from concentrating urine.

The hormones that control the kidneys’ concentrating abilities are not being produced or are not functioning properly.

A disease such as diabetes causes a marked elevation of certain substances (especially glucose or blood sugar) in the bloodstream. When the concentration of glucose in blood exceeds a certain level, the kidney can no longer prevent some from spilling into the urine. This results in a higher volume of urine and can eventually lead to a substantial fluid loss in the urine (hematuria)

Seeing blood in the urine can be frightening for both parent and child. But not everything that looks red is blood. It is not uncommon to see a small amount of pinkish red, paste like material in a newborn’s diaper. This is usually caused by urate crystals that form in concentrated urine. If these are seen in a breastfed baby, it may be helpful to nurse more frequently. If you are bottle-feeding, consider giving a few ounces of water. Urate crystals will usually disappear by the second week of life.

Some foods such as beets and certain medications cause a child’s urine to change color. You should consult with your child’s physician if this occurs.

Blood in an infant’s diaper area may come from the urinary tract, from the vagina in little girls, or from the gastrointestinal tract. If you notice blood in the diaper, take the diaper with you to your physician.

Blood in the urine is sometimes clearly visible but at other times may be present in quantities so small that it can be detected only by a microscopic evaluation and/or a dipstick-a thin test strip that identifies a variety of substances in the urine. The following conditions cause red blood cells to be present in the urine, and it is important that the underlying cause be determined if at all possible:

•Urinary tract infection

•Trauma, including injuries to the kidneys or genitalia

•Kidney diseases, including hereditary kidney problems, that leak small amounts of blood into the urine

•Kidney stones

•Blood-clotting problems

•Abnormalities of immune function

•Exposure to toxic substances

•Tumor, which in children would nearly always involve the kidney rather than ureter, bladder, or external genitalia

•Vigorous exercise-running, jumping, etc.

Your physician will examine your child and ask questions to sort through these possibilities. A urine specimen will be evaluated. If a urinary tract infection does not appear to be the problem, the physician will probably do a careful evaluation of the genital area and order special blood and/or imaging tests (X-ray or ultrasound)to help determine the cause of the hematuria.

Obstruction: hydronephrosis

Malformations of any portion of the urinary system can occur during fetal development. The most common ofthese in both girls and boys is an obstruction that decreases or completely stops the flow of urine. The resulting increase in pressure causes swelling within the urinary tract. When one or both kidneys are involved, the condition is called hydronephrosis (literally, “water kidney”). Sometimes this type of obstruction can be diagnosed during pregnancy through an ultrasound. One of the first surgeries developed for preborn babies was the treatment of hydronephrosis by removing the obstruction while the kidneys still had time to grow.

Obstruction: persistent urethral valves

In boys, the urine flows through the urethra inside the penis. During fetal development, small flaps called valves stop the flow of urine. Before the baby is born, these valves normally disappear, allowing urine to pass freely. If the flaps of tissue remain after birth, they can obstruct the urine flow and cause bladder distention. One clue that a baby may have urethral valves is that the urine stream is weak and dribbling rather than forceful. (Most parents of boys have been sprayed during diaper changes, an indication that the flow of urine is not obstructed.)

Obstruction: meatal stenosis

The opening at the end of the penis through which urine passes is called the meatus. If the baby boy is circumcised at birth, the head of the penis (glands) is exposed to urine and stool in the diaper. The sensitive cells of the meatus may become irritated and heal with scar tissue, which can cause a narrowing known as meatal stenosis.If the boy’s urine stream appears narrowed – a thin, jet like stream as if coming from a nozzle – or if it deviates to one side so much that he must deliberately aim his penis to keep the urine stream within the toilet bowl, he should be examined by a physician. If meatal stenosisis severe, a urologist may perform minor surgery to dialate the meatal opening.

Causes of Kidney Disease

by on Saturday, March 6, 2010 3:53 under Health.

Read full story

Several other well-known causes may produce progressive renal destruction.

Analgesic Nephropathy

In recent years one of the most notorious has been the overuse of analgesics (pain-killers). This originally concentrated on phenacetin, but it seems that other widely used analgesics are almost as potent, such as aspirin, probably paracetamol, and others when used in combination. The continued use of these easy-to-obtain drugs over a period of years can gradually destroy the fine filtering mechanism of the renal system. It may give rise to recurring infections with foul smelling urine containing blood.

Symptoms

The usual symptoms of urinary-tract infection exist. As well, there may be anaemia and pallor, due to the continual blood loss. Recurring fevers and aches and pains arc common symptoms.

There is a history of regular intake of analgesic compounds, often APC powders or tablets, either containing drug compounds or single drugs. If left, the gradual kidney destruction may lead to renal failure. In Australia about 15 per cent of the kidney transplant operations are attributed to phenacetin nephropathy. All could have been totally avoidable.

Women are cautioned against taking analgesics unless there is a definite medical reason. It is now generally conceded that drug combinations may produce trouble, and for this reason compounds (two or more drugs taken together) arc not recommended. It seems that use of a single drug (such as aspirin or paracetamol alone) will not cause serious harm. Nevertheless, the fewer drugs taken the better, and ideally any should be taken fbr the minimum period of time to alleviate symptoms.

Fortunately in the early stages, if drug taking is discontinued, the disorder is quite reversible. But if left, it will lead to serious kidney destruction and may be life-endangering.

Other Disorders

Other disorders may also lead to renal damage. It may take place when lead is persistently ingested. This may occur in children eating lead-containing paint, although this is now much less common than in years past.

Gout

This may lead to permanent kidney impairment as crystals of uric acid are laid down, gradually destroying the delicate kidney substance. Stones may form, producing attacks of renal colic. Most patients with gout have some renal involvement. Bouts of renal colic, blood in the urine, and uraemia may finally occur.

Elevated Blood Pressure

So often this is closely associated with renal disease. It may rarely cause symptoms. Treatment is the management of the elevated blood pressure.

Diabetes Mellitus (Sugar Diabetes)

This disorder is commonly associated with serious renal disease. If the diabetes is kept under control, the patient will live much longer, reaching an age group where vascular complications are becoming more common. Often the renal blood-vessel pathology runs in parallel with similar complications in other organs of the body, such as the heart, brain and limbs.

Renal disease is now one of the most common fatal complications of the diabetic. Careful therapy of the diabetic offers the best chance of prolonging life, but the beneficial effect of therapy is not as dramatic on the renal system as on the underlying disease.

Congenital Renal Disease

Many congenital anomalies occur in the kidney, but they are of little clinical importance in the total picture. There is some evidence that they are more prone to recurring infections, and if discovered and symptomatic, are best surgically corrected if possible. Solitary cysts or many cysts (fluid-filled spaces) may occur in the surface of the kidney or in its substance. The treatment is symptomatic.

Hydronephrosis

This condition occurs if there is some obstruction to the outflow of urine that banks up, causing dilation of the kidney spaces. Often there are no symptoms, the condition being found accidentally when a kidney X-ray is taken (intravenous pyelogram, or IVP) or other investigation carried out such as CT scan or ultrasound investigation. There may be blood in the urine, or symptoms of a urinary-tract infection leading to investigation. Renal infections may result, and these may cause the patient to seek treatment.